Academics

Bio

Dr. Manasi Mishra is an Associate Professor in Biosciences & Technology. She completed her Ph.D in Biotechnology from CSIR-National Chemical Laboratory, Pune, and received a short-term DAAD fellowship to conduct collaborative research at EMBL Hamburg, Germany. Her exceptional work in the field of biotechnology has earned her several prestigious fellowships, including the DST-INSPIRE Faculty Fellowship award from the Department of Science & Technology, and the Indo-Australian Career Boosting Gold Fellowships from the Department of Biotechnology, Government of India.

Dr. Mishra has a keen interest in plant immunity proteins and peptides, and her research has been focused on the structure-function correlation of diverse plant defense proteins, molecular diversity, and their functional significance. She is also actively working in the areas of protein/peptide engineering for therapeutic applications. Her valuable contributions to the field of biotechnology have helped advance the understanding of plant defense mechanisms and have the potential to impact the development of new therapeutic treatments.

Research Areas

"Plant defense proteins and peptides, Plant bioactive molecules, Botanical therapeutics, Molecular diversity and evolution, Protein and peptide engineering "

Publications

1. Mishra M, Singh V, Singh S (2019) Structural insights in to key Plasmodium proteases as therapeutic drug targets. Frontiers in Microbiology 10:394.

2. Mishra M* (2020) Evolutionary aspects of the structural convergence and functional diversification of Kunitz-domain inhibitors. Journal of Molecular Evolution 88(7): 537-548.

3. Mishra M#, Singh V#, Tellis MB, Joshi RS, Pandey KC, Singh S (2020) Cyclic peptide engineered from phytocystatin inhibitory hairpin loop as an effective modulator of falcipains and potent anti-malarial. Journal of Biomolecular Structure and Dynamics (https://doi.org/10.1080/07391102.2020.1848629).

4. Mishra M*, Singh V, Tellis MB, Joshi RS, Singh S* (2021) Repurposing the McoTI-II rigid molecular scaffold in to inhibitor of ‘papain superfamily’ cysteine proteases. Pharmaceuticals 14, 7: 1-17.

5. Gupta R, Kumari J, Pati S, Singh S, Mishra M*, Ghosh S* (2021) Interaction of cyclotide Kalata B1 protein with model cellular membranes of varied electrostatics. International Journal of Biological Macromolecules 191: 852-860.

6. Singh Y, Sharma R, Mishra M, Verma P, Saxena A (2022) Crystal structure of ArOYE6 reveals a novel C-terminal fold and mechanistic insights into the distinct class III OYEs from pathogenic fungi. The FEBS Journal 289, 18: 5531-5550. doi: 10.1111/febs.16445. [IF: 5.62]

Google Scholar link : https://scholar.google.cz/citations?hl=en&user=jKtDFa4AAAAJ

Scopus link : https://www.scopus.com/authid/detail.uri?authorId=57197922892

ORCID link : https://orcid.org/0000-0002-3304-9105

Research Grants

Indo-Australian Career Boosting Gold Fellowships (IACBGF 2018)

-INSPIRE Faculty Award (2015)

Short-Term Scholarship (DAAD) German Academic Exchange (2010)

NET-JRF (2006) , GATE (2006)